Recently, Chen et al. presented the largest single case series of patients with CHD2-related epilepsy and then comprehensively reviewed 53 published cases in the literature through seizure onset age, seizure types, developmental outcome, electroencephalogram (EEG), brain magnetic resonance imaging (MRI), and diagnoses, among others, which improved the understanding on the relationship between genotype and phenotype (Chen et al., 2020). The gene discussed is CHD2; the disease is epilepsy.