CHD2 and epilepsy: Up to now, a total of 9 patients with CHD2 variants were reported to have no epilepsy (Bhakta et al., 2005; Kulkarni et al., 2008; Chenier et al., 2014; Hamdan et al., 2014; Pinto et al., 2014; Chen et al., 2017; Cabrera-Salcedo et al., 2019), For example, Hamdan et al. found that a severe ID girl with motor and speech development delays and CHD2 variant c.335C>G (p. Ser112*) did not have the history of epilepsy (Hamdan et al., 2014).