KEGG pathway analysis showed that they were involved in rheumatoid arthritis–related pathways, the RAP1 signaling pathway, the PI3K/Akt signaling pathway, the calcium signaling pathway, the RAS signaling pathway, the MAPK signaling pathway, and the HIF-1 signaling pathway (Figures 3C,D). This evidence concerns the gene AKT1 and rheumatoid arthritis.