H2BC3 and cancer: Viral carcinogenesis has been identified as an abnormal pathway, and the enriched DEGs include HIST1H2BM, HIST1H2BO, HIST1H4K, ACTN3, HIST1H4L, HIST1H2BI, HIST1H2BL, HIST1H4A, HIST1H4B, CREB3L3, HIST1H2BH, HIST1H2BB, HIST1H4C, HIST1H4D, and HIST1H4F. The enriched genes are key components of histones; among them, HIST1H2BH was reported to participate in transcriptional mis-regulation in cancer pathways by regulating the response to catecholamine stimulus, limbic system development, and catecholamine metabolic process (Tian et al., 2019).