BDH2 and heart disorder: Besides, the expression levels of several other causal genes identified were also changed in heart function or cardiac diseases, such as HP, BDH2, NME7, PIGF, OXSM, PSMD10, and TRIM69. DOX decreased the expression of most hub genes; particularly, the decrease of RNF181 expression in both DOX and ISO cardiotoxicity models followed a similar manner.