RNF181 and coronary artery disorder: Additionally, we also identified another association for gene variance, rs1562322, with CAD (RNF181: OR = 0.76, p = 0.290648, FDR = 0.168875) (Supplementary Figure S5B–E), suggesting that risk variants rs6738645 and rs1562322 in the RNF181 locus may be associated with coronary heart disease.