The results showed that RNF181 correlated with the expression levels of ADAMTS7 and S100A6 (Figure 4A and Supplementary Figure S5A), two well-established variant genes associated with CAD (Bauer et al., 2015; Chan et al., 2017; Cai et al., 2011; Mofid et al., 2017). The gene discussed is S100A6; the disease is coronary artery disorder.