In general, our findings revealed distant associations between PLAGL2 expression with cancer purity and immune cells infiltration, such as B cells, CD8+T cells, CD4+T cells, and macrophages and neutrophils, while DCs revealed that PLAGL2 had a vital role in immune infiltration in GBM, which modulated the infiltration of immune cells to tumor tissues. Here, PLAGL2 is linked to glioblastoma.