PLAGL2 and cancer: Additionally, previous studies indicated that PLAGL2 was involved in the progression of various cancers, including colorectal cancer, lung adenocarcinoma, breast cancer, gastric cancer, and gastrointestinal cancer (Landrette et al., 2005; Hanks and Gauss, 2012; Xu et al., 2018; Li et al., 2019; Gao and Ye, 2020).