Meanwhile, PLAGL2 expression was also correlated with the expression of immune cell markers of various subsets of T-helper (Th) cells, including Th1 (TBX2), Th2 (CD14, GATA3, STAT6, and STAT5A), Tfh (BCL6), Th17(STAT3) and Tregs (FOXP3, STAT5B, and TGF-β), which also had a potential influence in regulating the tumor immunity infiltration of T-helper cells for PLAGL2. The gene discussed is BCL6; the disease is neoplasm.