Aberrant PLAG2 expression was found in the development of the expression of PLAGL2 bladder urothelial carcinoma, AML, gastrointestinal cancers, and glioblastoma (Landrette et al., 2005; Zheng et al., 2010; Liu et al., 2014; Li et al., 2019). This evidence concerns the gene PLAGL2 and glioblastoma.