We mainly performed PLAGL2 expression in GBM and the correlation between gene expression and abundance of immune infiltrates, involving B cells, CD8+ T cells, and CD4+ T cells, macrophages, neutrophils, dendritic cells (DCs), compared with purity in GBM and assessed how PLAGL2 is correlated with immune cell markers including CD8+T cells, T cells, B cells, monocytes, M1 macrophages, M2 macrophages, neutrophils, DCs, Th1 cells, type 2 helper T cells (Th2), Tfh cells, type 17 helper T cells (Th17), and Treg. This evidence concerns the gene CD4 and glioblastoma.