XBP1 and cancer: X-box-binding protein 1 (XBP1) is generated through the activation of the IRE1α-mediated cleavage of XBP1 mRNA cleavage (Dauer et al., 2019; Barez et al., 2020), which expression is associated with poor prognosis in cancer patients (Bagratuni et al., 2010; Chen et al., 2014; Kwon et al., 2018).