To further explore the function of ATF6, EMC6, and APAF1 in PC, we determined the effect of ATF6, EMC6, APAF1 on the proliferation and invasion abilities of PC cells using the CCK8 and Transwell assays on ATF6 transfected PC cell lines, SW1990 and ASPC1, EMC6 transfected PC cell lines, PATU8988 and SW 1990, APAF1 transfected cell lines, PANC1 and ASPC1. Here, APAF1 is linked to pachyonychia congenita.