Univariate Cox regression analysis revealed that the TNM stage, lymph node involvement, and the expression levels of ATF6, EMC6, and APAF1, significantly correlate with RFS, OS, and DSS, while no significant differences were observed between the two groups based on age, sex, smoking, tumor size, neural and vascular invasions, and XBP1 and CHOP expression (Tables 2–4). Here, APAF1 is linked to neoplasm.