BIRC5 and colorectal cancer: In addition, roburic acid induced the apoptosis of colorectal cancer cells by promoting the cleavage of PARP, Caspase3, Caspase7, and Caspase9, as well as downregulating the levels of the antiapoptotic proteins Bcl-2, Bcl-xL, XIAP, Mcl-1, and Survivin.