LncRNA IRF1-AS (Interferon Regulatory Factor 1 Antisense RNA) was an IFN-inducible nuclear lncRNA reported to repressed esophageal squamous cell carcinoma (ESCC) progression by promoting IFN response through a positive regulatory loop with IRF1 (Interferon Regulatory Factor 1). Here, IRF1 is linked to esophageal squamous cell carcinoma.