In addition, MMPs also participate in the reconstruction of tumor extracellular matrix and promote tumor progression; (c) Granule colony stimulating factor (G-CSF) and TGFβ can induce neutrophils to express arginase 1 (ARG1), ROS and nitric oxide (NO), to inhibit T cell activation; (d) Recruit anti-inflammatory M2 macrophages (67, 69, 70). Here, CSF3 is linked to neoplasm.