Lnc-epidermal growth factor receptor (EGFR), specifically bound to EGFR, blocked its interaction with c-CBL and c-CBL ubiquitination, upregulated its downstream AP-1/NF-AT1 axis, and then triggered EGFR Expression to promote Treg differentiation and HCC progression (164). The gene discussed is CBL; the disease is hepatocellular carcinoma.