○ Embryonic lethality of SGO1 fl/fl mice, SGO1fl/+ mice were normal.○ Mild chromosome segregation defects in SGO1fl/+ MEF.○ SGO1fl/+ mice had higher frequency of colonic tumors.○ SGO1fl/+ mice show higher IL6, p53, Bcl2. The gene discussed is SGO1; the disease is colonic neoplasm.