FCGR2B and systemic lupus erythematosus: Defects in the Fcγ receptor IIb(FcγRIIb) have been identified as genetic factors that increase susceptibility to lupus; the previous experiment on mice showed that H. pylori infection increases anti-dsDNA and promotes anti-dsDNA lupus seriousness in mice with the symptom of FcγRIIb-deficient lupus (133).