The armored B2ARM CAR successfully withstood TGF-β-mediated inhibition, and mediated greater expansion and tumor infiltration, degranulation and target cell killing, cytokine secretion, robust activation, differentiation to memory subsets and effector function, persistence and polyfunctionality in the presence of TGF-β, both in vitro and in vivo. Here, TGFB1 is linked to neoplasm.