In accordance to this, we show that in the presence of TGF-β, the non-armored B2 CAR T-cells had impaired differentiation to the TEMRA subset, even after continued engagement with MM cells, in contrast to the armored B2ARM CAR T-cells, which differentiated normally to the effector populations in response to MM cells, despite prolonged treatment with TGF-β. Here, TGFB1 is linked to Miyoshi myopathy.