Combined expression of KLK4-7 in ovarian cancer has been associated with increased level of TGF-β1, neural cell adhesion molecule L1 (L1CAM), and other tumor-associated factors such as keratin 19 and moesin, indicating the impact of KLK proteases on the secreted proteomes shaping tumor microenvironment (83, 84). The gene discussed is L1CAM; the disease is ovarian cancer.