It has been suggested that GzmB is involved in Treg-mediated suppression and elimination of activated CTL/NK cells and antigen-presenting cells, indicating Treg cells utilize GzmB to suppress immune responses and tumor clearance, thus depending on the relative abundance of these cells in the tumor, GzmB can have either detrimental or protective function in antitumor immunity (92, 93). The gene discussed is GZMB; the disease is neoplasm.