Combined expression of KLK4-7 in ovarian cancer has been associated with increased level of TGF-β1, neural cell adhesion molecule L1 (L1CAM), and other tumor-associated factors such as keratin 19 and moesin, indicating the impact of KLK proteases on the secreted proteomes shaping tumor microenvironment (83, 84). This evidence concerns the gene MSN and neoplasm.