MUC5AC and obesity due to melanocortin 4 receptor deficiency: Since A. muciniphila has been proposed as an anti-inflammatory key mucin-degrading bacterial strain that can protect against obesity and metabolic diseases and its abundance is regulated by the IL-36 family (17), we explored the role of A. muciniphila in the inflammatory response of adipocytes by analyzing the expression and release of IL-36γ.