Anlotinib (ANL) is a novel targeted vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit, and shows promising efficacy in patients with renal cell cancer (RCC) (14–16). The gene discussed is KDR; the disease is renal cell adenocarcinoma.