The lipid mediators metabolized from three major metabolic pathways of eicosanoids (the cyclooxygenase (COX), the lipoxygenase (LOX), and the cytochrome P450) play a critical role in immunoregulation, tumor immune microenvironment, crosstalk between metabolic reprogramming, and efficacy (9, 25, 26). Here, LOX is linked to neoplasm.