In a mouse model of allergic asthma, SGK1 deficiency significantly reduces Th2 cell differentiation, while bronchoalveolar lavage fluid from Sgk1 gene knockout mice has lower concentrations of IL-4 and IgE, and mice were, therefore, resistant to Th2 cell-mediated allergic asthma (20). This evidence concerns the gene IGHE and allergic asthma.