Granulocyte colony-stimulating factor (G-CSF)-mobilized donor grafts cause murine cGVHD with prominent scleroderma and high levels of Th17 cells, which recruit macrophages and produce higher level of profibrotic TGF-β, which are essential for lung and skin fibrosis (24, 25). The gene discussed is TGFB1; the disease is scleroderma.