As of 2007, encephalitis owing to anti-N-methyl-D-aspartate receptor (anti-NMDAR) was the most frequent AE subtype, followed by the subtypes due to anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-gamma aminobutyric acid B-receptor (anti-GABABR) antibody. The gene discussed is LGI1; the disease is encephalitis.