The presence of DN TILs has also been demonstrated within lymph node metastases of melanoma patients with tolerogenic behavior biomarkers such as CD30, and a significant increase in DN TILs was found in lymph nodes of patients with melanoma who had experienced disease progression compared to that in patients without disease progression, leading to the hypothesis that DN TILs contribute to tumor metastatic progression (93, 94) (Figure 3). Here, TNFRSF8 is linked to melanoma.