Immune profiling of hepatocellular carcinoma (HCC)-infiltrating cells showed two unique populations of DN T cells: one cluster of DN T cells is TCRγδ+, coexpressing the tissue-resident markers CD69 and CD103 and the activation marker CD38, and the other cluster is TCRαβ+, with expression of the activation markers CD150, CD69, CD137 and HLA-DR and the inhibitory TIGIT molecule. This evidence concerns the gene TIGIT and hepatocellular carcinoma.