Some pieces of evidence had already demonstrated that NLRP3 inflammasome activation could induce significant changes in different body systems affected by sepsis, among which, the effects of NLRP3 inflammasome on the respiratory system includes immunological influences like edema formation, neutrophil infiltration, and elevated levels of inflammatory cytokines such as IL-1β and IL-18 in the lung tissue (26). The gene discussed is IL18; the disease is Sepsis.