In this study, by screening a large number of chemical compounds, we identified 4-[2-(1H-indol-3-yl)-1,3-thiazol-4-yl] benzene-1,2-diol (1,2-diol), a 4-benzene-indol derivative, suppressed NLRP3 inflammasome activation both in vitro and alleviates LPS-induced ALI in vivo. Here, NLRP3 is linked to acute respiratory distress syndrome.