The results showed that 1,2-diol could not only suppress the activation of NLRP3 inflammasome both in vitro and alleviate LPS-induced ALI in vivo, but also suppress the NLRP3 inflammasome in human myeloid leukemia mononuclear cells (THP-1) cell lines. The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.