Despite the resistance of B6 wild type (WT) mice to TMEV infection, 80% (8/10) of DA-infected IFN-β-/- mice had to be killed at 7 days post infection (dpi) and another 20% (2/10) at 8 dpi due to severe clinical disease, whereas all BeAn-infected mice (10/10) survived (Figure 1). Here, IFNB1 is linked to infection.