CD83 and autoimmune disease: While our human anti-human CD83 mAb 3C12C has shown the ability to deplete mature cDC and limit T cell responses in in vitro MLR experiments and xenogeneic graft-versus-host disease models (21), the ability to test the efficacy of this reagent in other inflammatory conditions such as autoimmune disease was limited by the dearth of animal models available to test human antibodies.