Although idebenone, a ubiquinone analogue, has neuroprotective effects in Aβ-treated rat hippocampal cultures and memory-enhancing effects in Aβ-treated WT mice (16, 41), the effects of idebenone on Aβ-associated neurogliosis or NLRP3 activation have not been fully investigated in a mouse model of AD. This evidence concerns the gene NLRP3 and Alzheimer disease.