NET formation in normoxia or hypoxia setups was evaluated by (I) stimulation of isolated human peripheral blood neutrophils, and (II) collection of human tissue samples from acute myocardial infarction and other neutrophil-rich diseases without overt hypoxia through immunohistochemical analysis of HIF-1α and neutrophil elastase (NE). The gene discussed is ELANE; the disease is myocardial infarction.