Within the CD4+ T cell compartment, children with DS showed elevated levels of CD45RA-CCR7+ central memory T cells (CM) (p=0.006) and CD45RA-CCR7- effector memory T cells (EM) (p<0.0001), whereas CD45RA+CCR7- effector memory cells re-expressing RA (EMRA) were similar in both groups (Figure 3C). The gene discussed is CCR7; the disease is Dravet syndrome.