During their development in the thymus, T-cells undergo positive and negative selection, where T-cells recognizing self-antigen MHC complexes with low to moderate affinity undergo proliferation, whereas strong interactions with high affinity self-antigen MHC complexes leads to cell death, preventing autoimmunity, while some of the cells differentiate into regulatory T-cells (Takaba and Takayanagi, 2017). Here, HLA-C is linked to Autoimmunity.