A similar finding was reported for proteolytic protein (PLP) involved in multiple sclerosis (MS) (Markovic-Plese et al., 1995) and thyroid peroxidase (TPO) involved in Grave’s disease (Quaratino et al., 1996) where the antigenic peptides significantly differed for both endogenously and exogenously processed TPO proteins. The gene discussed is TPO; the disease is myeloid sarcoma.