In this study, we retrospectively collected data on HIV patients receiving ART in Guangxi from the Chinese National Free Antiretroviral Treatment Program (NFATP) database to evaluate the incidence of CKD and the recovery of the CD4/CD8 ratio among HIV patients receiving ART who initially had a normal eGFR and to investigate the association of the CD4/CD8 ratio recovery and CKD among these patients with different ART regimens. This evidence concerns the gene CD8A and chronic kidney disease.