CD8A and chronic kidney disease: In addition, we found that the median CD4 cell count in the NNRTI-based group was lower than that in PI-based or INSTI-based groups when CD4/CD8 ratio recovered, however, the incidence of CKD in NNRTI-based group was the lowest (Supplementary Table 3), indicating that although CD4 cell count of some participants did not return to normal level, the risk of CKD could be partially reduced as long as the CD4/CD8 ratio was restored.