Univariate Cox regression analysis showed that patients whose CD4/CD8 ratio did not recover to 0.7 (HR = 2.87, 95% CI 2.67–3.08) had a higher risk of developing CKD than those did not recover to 1.0 (HR = 1.33, 95% CI 1.22–1.46) (Supplementary Table 2). This evidence concerns the gene CD4 and chronic kidney disease.