This method has been widely used (Yang et al., 2018; Xu et al., 2019), and many studies have shown that Aβ (1-42) injection can cause memory impairment and changes Brain Derived Neurotrophic Factor (BDNF) or 5-hydroxytryptamine(2A)[5-HT(2A)] receptor levels in the serum and brain (O’Hare et al., 1999; Christensen et al., 2008). Here, BDNF is linked to memory impairment.