Some studies have suggested that accumulation of Aβ in the brain is the primary influence driving AD pathogenesis (Gitter et al., 2000; Hardy and Selkoe, 2002), and others show that tau protein hyperphosphorylation leads to neurofibrillary tangles, resulting in neurotoxicity (Iqbal et al., 2016; Wesseling et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.