TMPRSS2 is already well established as an important marker for the ease of viral entry (Andolfo et al., 2020; Asselta et al., 2020; Latini et al., 2020; Sajuthi et al., 2020; Senapati et al., 2020; Vastrad et al., 2020; Wang et al., 2020c; Mohammad et al., 2021; Schönfelder et al., 2021; Torre-Fuentes et al., 2021), while MX1 is a gene responsive to interferon and is closely directed to the activity of response to viral infections, including SARS-CoV-2 infection (Russo et al., 2020; Bizzotto et al., 2020). This evidence concerns the gene TMPRSS2 and viral infectious disease.