EIF2AK3 and infection: However, prototype foamy virus (PFV) infection induced a complete autophagic process through ER stress containing PERK, IRE1, and ATF6 branches and increased the activation of autophagy to inhibit PFV replication, which implies that PFV-induced autophagy has a novel mechanism and plays an antiviral role in viral replication (Yuan et al., 2017).