Brossaud and colleagues included patients in which mild Cushing was defined as serum cortisol > 50 nmol/l after 1 mg DST and at least one of the following endocrine alterations: mildly increased UFC (≤1.5 ULN), suppressed plasma ACTH levels (< 10 pg/ml) in patients with adrenal tumours, late-night salivary cortisol or midnight serum cortisol. The gene discussed is POMC; the disease is adrenal gland neoplasm.