Consistently, we demonstrated that patients with MAFLD had significantly higher BMI, WC, ALT, AST, γ-GT, TG, FINS, HOMA-IR, and CRP levels as well as increased proportions of obesity, hypertension, hyperlipidemia, IR, hepatic steatosis, and fibrosis compared with those without MAFLD in both genders. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.