Despite being aware that the detection of monomorphous ovoid cells with endocrinoid network of vessels, microcalcifications, and desmoplasia on a high-grade glioma, IDHwt might justify the search for FGFR3-TACC3 fusions, the authors concluded that morphology alone could not predict the molecular status of these rare subsets of GBMs, as some FGFR3-TACC3-fused cases, that lacked these peculiar features, occurred, and, conversely, GBM cases, exhibiting this unusual morphology, lacked the FGFR3-TACC3 fusion. The gene discussed is FGFR3; the disease is central nervous system cancer.