As a potentially treatable condition, one should always consider autoimmune diseases: for examples, lupus erythematosus, antiphospholipid syndrome (anti-nuclear, anti-DNA, antiphospholipid antibodies), celiac disease (gliadin and transglutaminase antibodies), primary Sjögren, anti-SSB [anti-SSA (Sjögren syndrome antigen A and B)], thyroid antibodies in Hashimoto's encephalopathy (Thyroid peroxidase, thyroglobulin antibodies) (50, 51). The gene discussed is TPO; the disease is antiphospholipid syndrome.