APOE and Mental deterioration: Finally, while these markers alone may have relatively low predictive value for diagnostic uses, future combination of exosome cargo markers with other moderators of neurodegenerative risk, (i.e., polygenic risk scores for neurodegenerative disorders or Apolipoprotein E (APOE) genotype) may be useful in conjunction with exosome cargo proteins in developing predictive markers of functional outcome such as long-term cognitive decline after TBI.