NPPB and heart failure: The Association of Change in N-Terminal pro-B-Type Natriuretic Peptide (NT pro-BNP) Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction (PROVE HF) trail reported that SV improved NT-proBNP concentrations, left ventricular ejection faction (LVEF), left ventricular end-diastolic volume index (LVEDVi), and left ventricular end-systolic volume index (LVESVi) in HFrEF patients (Januzzi et al., 2019).