S107 is more specific for RyR2 and FKBP12.6 binding, reducing Ca2+ leak and preventing arrhythmia in a mouse model of CPVT (Lehnart et al., 2008) and decreasing DADs in hiPSC-derived cardiomyocytes (Sasaki et al., 2016). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.