For example, in hypertensive rats induced by either the DOC-salt or the 2K1C model, levels of immunoreactive CGRP in the spinal cord and α-CGRP mRNA in DRG were elevated in order to stimulate vasodilation and combat the developing hypertension (Supowit et al., 1995a,1997, 1998). This evidence concerns the gene CALCA and Hypertension.