In vascular cognitive impairment and dementia (often coexisting with AD, the second leading cause of dementia after AD) mouse models, Sudduth et al. (2017) demonstrated the destruction of astrocyte terminal protrusions and a decrease in DP71, AQP4, and Kir4.1 localization along with neuroinflammation and cognitive dysfunction. This evidence concerns the gene AQP4 and dementia.