MAPT and Alzheimer disease: Furthermore, pentylenetetrazole (an inducer of epilepsy)-treated Fyn [an Src family kinase which can be activated by Aβ and interacts with tau, co-localizing with tau in the hippocampus of AD (Nisbet and Götz, 2018)] KO, tau KO, and double KO mice exhibit less inhibition of Kir4.1 in astrocytes compared to the control group as well as reduced gliosis and neurodegeneration (Figure 1) (Putra et al., 2020).