In addition, increasing the concentration of K+ in the brain tissue of a normal mouse also caused pathological manifestations similar to those in a HD group, suggesting that impairment of Kir4.1 channels in astrocytes in HD can lead to the abnormal transport and distribution of K+, which caused neuronal dysfunction (Khakh and Sofroniew, 2014). Here, KCNJ10 is linked to Huntington disease.