SOD1 and metabolic dysfunction-associated steatotic liver disease: However, silencing FOXO3 decreased its downstream SOD activity and increased the levels of lipid peroxidation product MDA and inflammatory cytokines in miR-122-5p inhibitor-treated NAFLD mice, indicating that miR-122-5p may be an important negative regulator for the FOXO3-mediated antioxidant stress signaling pathway.