Recently, abundant evidence from our group strongly supports PRR as an important regulator of intrarenal RAS during water deprivation (Wang et al., 2016), angiotensin II-induced hypertension (Wang et al., 2014, 2017) and chronic kidney injury (Fang et al., 2018), favoring PRR as integrative member of the RAS. The gene discussed is ATP6AP2; the disease is hypertensive disorder.