Increased expression of the cytokine-responsive TF CCAAT-enhancer binding protein-delta (CEBPD) has been observed in the brains of AD patients (Li et al., 2004), the APP/PS1 AD mouse model (Ko et al., 2012) and, notably, in astrocytes treated with pro-inflammatory cytokines (Chu et al., 2016) or surrounding Aβ plaques (Li et al., 2004). Here, APP is linked to Alzheimer disease.