Following analysis of plasma leptin levels collected at timepoint 0 during the OGTT on P18 (Figure 6D), main effects of phenotype (F1,44 = 4.891, P = 0.032) and diet: (F1,44 = 7.571, P = 0.009) were detected, with Tukey’s multiple comparisons test revealing a significant difference between the leptin levels in DR-Chow vs. DIO-HE dams (P = 0.010). This evidence concerns the gene LEP and hereditary elliptocytosis.