PLOD1 and polycystic ovary syndrome: Previous studies showed that tonic hypersecretion of LH during the follicular phase was associated with a significant decrease in the quality of both oocytes and embryos, resulting in reduced pregnancy rates and higher miscarriage rates among women with PCOS (Howles et al., 1986; Homburg et al., 1988; Tarlatzis and Grimbizis, 1997; van der Spuy and Dyer, 2004; Dumesic et al., 2008; Franks et al., 2008; Qiao and Feng, 2011).