tIn conclusion, our present study systematically analyzed the related targets and signaling pathways of Jingyin granule against PF and conducted an in vitro experiment and demonstrated that Jingyin granule obviously inhibited the activation of JAK2/STAT3, NF-κB, PI3K/AKT, TNF, and ERK1/2 signaling pathways in LPS-induced PF. The gene discussed is MAPK3; the disease is pemphigus foliaceus.