Based on the results of the PPI network, active compounds–disease targets network, and literature data, seven components (arctigenin, quercetin, luteolin, kaempferol, rutin, gallic acid, and chlorogenic acid) and eight targets (AKT1, JAK2, MAPK1, MAPK3, RELA, PI3K, STAT3, and TNF) played crucial roles in anti-PF. This evidence concerns the gene RELA and pemphigus foliaceus.