The present study further demonstrated that the Ang II-induced elevation of SBP and vascular remodeling and dysfunction in mice are dose-dependently attenuated by a VCAM-1 neutralizing antibody (Figures 2–4), demonstrating that VCAM-1 contributes to the development of hypertension and vascular dysfunction induced by Ang II infusion. Here, VCAM1 is linked to hypertensive disorder.