PCSK9 and coronary artery disorder: The FOURIER trial then investigated the efficacy of PCSK9 inhibition in patients with stable coronary artery disease in different hs-CRP strata and found that the positive cardiovascular effects of PCSK9 inhibition were certain regardless of baseline hs-CRP, with patients with higher baseline hs-CRP showing the greatest benefit with PCSK9 inhibition (Bohula et al., 2018).