The relationship between changes in albumin and sAlb and prognosis in patients transitioning from CKD to ESRD stage was studied for the first time in 2019. Patients just transitioning from CKD to ESRD have a high short-term mortality rate, so improving the nutritional status of pre-ESRD patients, including sAlb levels, is important for the prognosis of such patients (Miller-Hodges et al., 2018). lower pre-ESRD sAlb is significantly associated with higher all-cause, cardiovascular and infection-related mortality and hospitalization rates after ESRD (Twerenbold et al., 2018). This evidence concerns the gene ALB and infection.