PCSK9 and cardiovascular disorder: 2021 Vlad et al. found no significant difference in PCSK9 levels in patients with different CKD stages, but PCSK9 > 220 ng/ml was a predictor of cardiovascular events, and PCSK9 > 220 ng/ml and hsCRP >3 mg/L together suggested an increased risk of kidney disease and cardiovascular disease (Vlad et al., 2021).