SOD isomers are important internal enzymes against oxidative stress, and SOD-1, an important isomer of SOD in the kidney, is associated with impaired renal function and reduced renal excretion capacity, so increased SOD-1 synthesis is observed in HD patients (Pawlak et al., 2007; Pawlak et al., 2013). The gene discussed is SOD1; the disease is Huntington disease.