IL6 and chronic kidney disease: IL-6 is the only independent predictor of the risk of cardiovascular comorbidity, cardiac mortality, and all-cause mortality in patients with CKD, better reflects the relationship between inflammation and cardiovascular complications than other cytokines (Kisic et al., 2016) and is the most reliable predictor of cardiovascular mortality and total mortality found in patients with CKD (Barreto et al., 2010; Sun et al., 2016).