TNNI3 and chronic kidney disease: This can be interpreted as using the degree of change in troponin as a diagnostic indicator, i.e., it is considered more diagnostic when patients with CKD have a >280% increase in high-sensitivity troponin I (hs-cTnI) or a >250% increase in high-sensitivity troponin T (hs-cTnT), but this also reduces the sensitivity of the diagnosis (Kraus et al., 2018).