Expression of nuclear receptors PPAR and FXR in HSCs suppress HSCs activation, as studies have shown that HSC senescence can be invoked by PPARγ, FXR agonist, such as GW570 (Krützfeldt et al., 2005; Janssen et al., 2013; Thakral and Ghoshal, 2015), pioglitazone (Krützfeldt et al., 2005; Janssen et al., 2013; Thakral and Ghoshal, 2015), obeticholic acid (Krützfeldt et al., 2005; Janssen et al., 2013; Thakral and Ghoshal, 2015), thereby alleviating liver fibrosis degree. This evidence concerns the gene NR1H4 and Hepatic fibrosis.