TGFB1 and Hepatic fibrosis: Activated inflammatory cells are the primary source of cytokines, such as C-C chemokine ligands types 2 and 5 (CCL2 and CCL5), IL, TGF-β1, PDGF, etc. The role of inflammatory cells is double-sided, which could promote the regression of liver fibrosis and accelerate the deterioration of fibrosis.