PRDM16 and migraine disorder: The rs2651899 polymorphism in the PRDM16 gene encoding the PR domain containing 16 proteins, a zinc finger transcription factor, appears to be associated with a better therapy efficacy of triptans in migraine, as shown in a Danish study including 1,806 patients, of which 1,386 reported an effect of triptans and 376 reported no effect (Christensen et al., 2016).