ITGAL and migraine disorder: In this study investigating the effect of migraine prophylaxis in 185 individuals using verapamil, the strongest decrease in the number of days with a headache after treatment was seen in carriers of the variant rs2230433 in the ITGAL gene, which encodes the integrin alpha L chain of a heterodimeric integral membrane receptor protein that is involved in costimulatory signaling and intercellular adhesion (Cutrer et al., 2021).