Also, significantly associated with headache reduction was rs10882386 in PLCE1. PLCE1 encodes a phospholipase C enzyme that catalyzes the hydrolysis of 1‐phosphatidyl‐1D‐myo‐inositol 4,5‐bisphosphate (Lopez et al., 2001; Smrcka et al., 2012). This evidence concerns the gene PLCE1 and Headache.