TSPAN2 and migraine disorder: In migraineurs, only nominal significant associations between a polymorphism in LRP1 (rs 11172113) encoding the low-density lipoprotein receptor-related protein 1 (lower efficacy), rs12134493 near the tetraspanin 2 gene TSPAN2, and rs6790925 near the transforming growth factor, beta receptor II gene TGFBR2 and rs10504861 near the matrix metalloproteinase-16 gene MMP16 (better efficacy) have been found for migraine patients treated with sartans (Christensen et al., 2016).