MMP16 and migraine disorder: Based on data from the Danish Headache Centre, the effectiveness of anticonvulsant treatment in all types of migraine in humans is increased in the case of polymorphism rs10504861 near MMP16, whereas in the case of PRDM16 variant rs2651899, the effectiveness of anticonvulsant treatment of migraine without aura is reduced as investigated in 365 migraine cases (Christensen et al., 2016).