The mechanisms by which ARBs and ACE inhibitors act beneficially in migraine are not fully understood, but it is possible that their effectiveness is due to the blockade of type ATII receptors and decrease of the influence of angiotensin II in cerebral vessels, which reduces the tone of smooth muscles and increases their resistance to vasospastic stimuli; in addition, the decrease in aldosterone production under the action of ARBs may play a role (Tronvik et al., 2006). The gene discussed is ACE; the disease is migraine disorder.