CASP3 and familial pancreatic carcinoma: In 2020, Chen et al. found that Sinomenine can inhibit the activation of NF-κB mediated apoptotic pathways, down-regulate the expression of tumor cell anti-apoptotic factors and apoptosis inhibitor proteins, promote the lysis of Caspase-3, and promote pancreatic cancer Capan-1 apoptosis (Chen et al., 2020).