In the same year, Huang et al. found that Icariin increased the apoptosis rate of pancreatic cancer BxPC-3 cells, the expression of apoptosis marker proteins Bax and Cleaved Caspase-3, and down-regulated the expression of apoptosis marker protein Bcl-2 (Huang et al., 2021). Here, BAX is linked to familial pancreatic carcinoma.