Further research found that Capsaicin prolonged the survival rate of nude mice with orthotopic pancreatic cancer xenograft tumors.The results of western blot analysis showed that the protein expression of GRP78, phospho-PERK, phospho-eIF2α, ATF4 (eIF2 α downstream target), and GADD153 was much higher in the tumor tissues of Capsaicin-treated mice compared with that of control group. The gene discussed is HSPA5; the disease is familial pancreatic carcinoma.