CASP3 and familial pancreatic carcinoma: In 2012, Wang et al. found that Triptolide can induce apoptosis in pancreatic cancer cells by down-regulating DcR3 and up-regulating FADD, down-regulating DcR3 promoted the cleavage of Bid and Caspase-3 and the activation of Caspase-8 was also found.