CASP3 and familial pancreatic carcinoma: Tang et al. also found that Ginsenoside Rh2 can down-regulate Bcl-2 and surviving, and up-regulate Bax, promote the cleavage of Caspase-3 and Caspase-9, and initiate the endogenous apoptotic pathway to induce BxpC-3 pancreatic cancer apoptosis (Tang et al., 2013).