EIF2AK3 and familial pancreatic carcinoma: In 2013, Lee et al. investigated the mechanism of Quercetin inducing apoptosis in pancreatic cancer, found that Quercetin went through the ERS mediated apoptotic pathway which induced the increase of GADD153/CHOP protein expression finally by increasing Grp78/Bip protein as well as activating PERK protein in PANC-1 cells.