CASP3 and familial pancreatic carcinoma: In this experiment, it was also found that Isoalantolactone can increase the level of ROS in PANC-1 cells in a dose-dependent manner, increase the expression of p38 and Bax, and accompanied by the release of Cyt-C and the activation of Caspase-3, it supports the view that Isoalantolactone induces pancreatic cancer PANC-1 cell apoptosis through an endogenous pathway (Ding., 2012).