MAPT and Alzheimer disease: A neurotrophic peptidergic compound, P021, which could rescue neurogenesis and neuronal plasticity deficits, was found to reverse cognitive impairment, prevent amyloid plaque and tau pathologies, and dramatically reduce the rate of mortality in 3xTg-AD, a transgenic mouse model of AD (Kazim et al., 2014; Baazaoui and Iqbal, 2017).