O-GlcNAcylation modulates several pathways involved in AD pathogenesis, such as APP processing (Jacobsen and Iverfeldt, 2011), tau phosphorylation (Liu et al., 2004, 2009), synaptic integrity (Tallent et al., 2009), and insulin signaling (Yang et al., 2008). This evidence concerns the gene INS and Alzheimer disease.