MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by the deposition of extracellular amyloid plaques composed of highly aggregated amyloid beta (Aβ) peptides Aβ40 and Aβ42, as well as intracellular neurofibrillary tangles (NFTs) consisting of hyper-phosphorylated tau protein, progressive atrophy, and cognitive decline (Alzheimer’s Association, 2015; Knopman et al., 2021).